The PRO-ACT database: design, initial analyses, and predictive features.

ABSTRACT:

Objective

To pool data from completed amyotrophic lateral sclerosis (ALS) clinical trials and create an open-access resource that enables greater understanding of the phenotype and biology of ALS.

Methods

Clinical trials data were pooled from 16 completed phase II/III ALS clinical trials and one observational study. Over 8 million de-identified longitudinally collected data points from over 8,600 individuals with ALS were standardized across trials and merged to create the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database. This database includes demographics, family histories, and longitudinal clinical and laboratory data. Mixed effects models were used to describe the rate of disease progression measured by the Revised ALS Functional Rating Scale (ALSFRS-R)

SUBMITTER: Atassi N 

PROVIDER: S-EPMC4239834 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature