Elevated rates of intracerebral hemorrhage in individuals from a US clinical care HIV cohort.

ABSTRACT:

Objective

To compare rates of intracerebral hemorrhage (ICH) in HIV-infected and uninfected individuals in a large clinical care cohort and to assess risk factors associated with ICH.

Methods

We identified incident ICH in HIV-infected and uninfected control cohorts from the Partners Health Care system using ICD-9-CM codes. We constructed Cox proportional hazards models to estimate adjusted hazard ratios for HIV infection and other predictors of ICH.

Results

The incidence rate of ICH was 2.29 per 1,000 person-years in HIV-infected individuals compared with 1.23 per 1,000 person-years in uninfected individuals, with an unadjusted incidence rate ratio of 1.85 (95% confidence interval 1.37-2.47, p < 0.001). In a multivariable model, HIV infection was independently associa

SUBMITTER: Chow FC 

PROVIDER: S-EPMC4239837 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature