Population pharmacokinetics and haemodynamic effects of norepinephrine in hypotensive critically ill children.

ABSTRACT:

Aim

The aim of the study was to investigate the pharmacokinetics and pharmacodynamics of norepinephrine in hypotensive critically ill children, including associated variability factors.

Methods

This was a prospective study in an 18-bed neonatal and paediatric intensive care unit. All children were aged less than 18 years, weighed more than 1500 g and required norepinephrine for systemic arterial hypotension. The pharmacokinetics and haemodynamic effects were described using the non-linear mixed effect modelling software MONOLIX.

Results

Norepinephrine dosing infusions ranging from 0.05 to 2 μg kg(-1)  min(-1) were administered to 38 children whose weight ranged from 2 to 85 kg. A one compartment open model with linear elimination adequately described the norepinephrin

SUBMITTER: Oualha M 

PROVIDER: S-EPMC4239982 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature