Properties and determinants of codon decoding time distributions.

ABSTRACT:

Background

Codon decoding time is a fundamental property of mRNA translation believed to affect the abundance, function, and properties of proteins. Recently, a novel experimental technology--ribosome profiling--was developed to measure the density, and thus the speed, of ribosomes at codon resolution. Specifically, this method is based on next-generation sequencing, which theoretically can provide footprint counts that correspond to the probability of observing a ribosome in this position for each nucleotide in each transcript.

Results

In this study, we report for the first time various novel properties of the distribution of codon footprint counts in five organisms, based on large-scale analysis of ribosomal profiling data. We show that codons have distinctive footprint co

SUBMITTER: Dana A 

PROVIDER: S-EPMC4240079 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature