Viral diversity and clonal evolution from unphased genomic data.

ABSTRACT:

Background

Clonal expansion is a process in which a single organism reproduces asexually, giving rise to a diversifying population. It is pervasive in nature, from within-host pathogen evolution to emergent infectious disease outbreaks. Standard phylogenetic tools rely on full-length genomes of individual pathogens or population consensus sequences (phased genotypes).

Methods

We introduce two measures of diversity to study the evolution of clonal populations using unphased genomic data, which eliminate the need to construct full-length genomes. Our method follows a maximum likelihood approach to estimate evolutionary rates and times to the most recent common ancestor, based on a relaxed molecular clock model; independent of a growth model. Deviations from neutral evolution i

SUBMITTER: Khiabanian H 

PROVIDER: S-EPMC4240099 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature