SUV39H1 downregulation induces deheterochromatinization of satellite regions and senescence after exposure to ionizing radiation.

ABSTRACT: While the majority of cancer patients are exposed to ionizing radiation during diagnostic and therapeutic procedures, age-dependent differences in radiation sensitivity are not yet well understood. Radiation sensitivity is characterized by the appearance of side effects to radiation therapy, such as secondary malignancies, developmental deficits, and compromised immune function. However, the knowledge of the molecular mechanisms that trigger these side effects is incomplete. Here we used an in vitro system and showed that low-senescent normal human diploid fibroblasts (WI-38) senesce in response to 5 Gy IR, while highly senescent cultures do not show changes in cell cycle regulation and only a slight increase in the percentage of senescent cells. Our study shows that this is associated wit

SUBMITTER: Sidler C 

PROVIDER: S-EPMC4240170 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature