Functional connectivity in autosomal dominant and late-onset Alzheimer disease.

ABSTRACT:

Importance

Autosomal dominant Alzheimer disease (ADAD) is caused by rare genetic mutations in 3 specific genes in contrast to late-onset Alzheimer disease (LOAD), which has a more polygenetic risk profile.

Objective

To assess the similarities and differences in functional connectivity changes owing to ADAD and LOAD.

Design, setting, and participants

We analyzed functional connectivity in multiple brain resting state networks (RSNs) in a cross-sectional cohort of participants with ADAD (n = 79) and LOAD (n = 444), using resting-state functional connectivity magnetic resonance imaging at multiple international academic sites.

Main outcomes and measures

For both types of AD, we quantified and compared functional connectivity changes in RSNs as a function of dement

SUBMITTER: Thomas JB 

PROVIDER: S-EPMC4240274 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature