GnRH agonists induce endometrial epithelial cell apoptosis via GRP78 down-regulation.

ABSTRACT:

Background

Endometriosis is a benign chronic gynecological disease that affects women of reproductive age, characterized by the presence of functional endometrial tissues outside the uterine cavity. GnRH agonists exhibit anti-proliferative and apoptosis-enhancing activities and have long been used for the treatment of endometriosis. There is a critical need to identify the signaling modules involving GnRH agonist therapy for the treatment of endometriosis. In this study, we compared the proteomic profiles of endometriosis in patients before and after GnRH agonist therapy to identify proteins that might provide further information concerning the mechanisms underlying the functions of GnRH agonists.

Methods

A total of 55 protein spots with different abundances were observed us

SUBMITTER: Weng H 

PROVIDER: S-EPMC4240864 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature