Plasma kininogen and kininogen fragments are biomarkers of progressive renal decline in type 1 diabetes.

ABSTRACT: The ability of microalbuminuria to predict early progressive renal function decline in type 1 diabetic patients has been questioned. To resolve this, we determined the plasma proteome differences between microalbuminuric patients with type 1 diabetes and stable renal function (controls) and patients at risk for early progressive renal function decline (cases) and asked whether these differences have value as surrogate biomarkers. Mass spectrometry was used to analyze small (<3 kDa) plasma peptides isolated from well-matched case and control plasma obtained at the beginning of an 8-12 year follow-up period. A Spearman analysis of plasma peptide abundance and the rate of renal function decline during follow-up identified seven masses with a significant negative correlation with early progres

SUBMITTER: Merchant ML 

PROVIDER: S-EPMC4241022 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature