Effects of adiponectin on calcium-handling proteins in heart failure with preserved ejection fraction.

ABSTRACT:

Background

Despite the increasing prevalence of heart failure with preserved ejection fraction (HFpEF) in humans, there remains no therapeutic options for HFpEF. Adiponectin, an adipocyte-derived cytokine, exerts cardioprotective actions, and its deficiency is implicated in the development of hypertension and HF with reduced ejection fraction. Similarly, adiponectin deficiency in HFpEF exacerbates left ventricular hypertrophy, diastolic dysfunction, and HF. However, the therapeutic effects of adiponectin in HFpEF remain unknown. We sought to test the hypothesis that chronic adiponectin overexpression protects against the progression of HF in a murine model of HFpEF.

Methods and results

Adiponectin transgenic and wild-type mice underwent uninephrectomy, a continuous saline or

SUBMITTER: Tanaka K 

PROVIDER: S-EPMC4241144 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature