Phenotypic instability between the near isogenic substrains BALB/cJ and BALB/cByJ.

ABSTRACT: Closely related substrains of inbred mice often show phenotypic differences that are presumed to be caused by recent mutations. The substrains BALB/cJ and BALB/cByJ, which were separated in 1935, have been reported to show numerous highly significant behavioral and morphological differences. In an effort to identify some of the causal mutations, we phenotyped BALB/cJ and BALB/cByJ mice as well as their F1, F2, and N2 progeny for behavioral and morphological phenotypes. We also generated whole-genome sequence data for both inbred strains (~3.5× coverage) with the intention of identifying polymorphic markers to be used for linkage analysis. We observed significant differences in body weight, the weight of the heart, liver, spleen and brain, and corpus callosum length between the two substrai

SUBMITTER: Sittig LJ 

PROVIDER: S-EPMC4241159 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature