Use of pressure-volume conductance catheters in real-time cardiovascular experimentation.

ABSTRACT:

Background

Most applications of pressure-volume conductance catheter measurements assess cardiovascular function at a single point in time after genetic, pharmacologic, infectious, nutritional, or toxicologic manipulation. Use of these catheters as a continuous monitor, however, is fraught with complexities and limitations.

Methods

Examples of the limitations and optimal use of conductance catheters as a continuous, real-time monitor of cardiovascular function are demonstrated during inotropic drug infusion in anesthetised rats.

Results

Inotropic drug infusion may alter ventricular dimensions causing relative movement of a well-positioned catheter, generating artifacts, including an abrupt pressure rise at end-systole that leads to over estimation of indices of contra

SUBMITTER: Wei AE 

PROVIDER: S-EPMC4241179 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature