Age and gender modulate the neural circuitry supporting facial emotion processing in adults with major depressive disorder.

ABSTRACT:

Objectives

Emotion processing, supported by frontolimbic circuitry known to be sensitive to the effects of aging, is a relatively understudied cognitive-emotional domain in geriatric depression. Some evidence suggests that the neurophysiological disruption observed in emotion processing among adults with major depressive disorder (MDD) may be modulated by both gender and age. Therefore, the present study investigated the effects of gender and age on the neural circuitry supporting emotion processing in MDD.

Design

Cross-sectional comparison of fMRI signal during performance of an emotion processing task.

Setting

Outpatient university setting.

Participants

One hundred adults recruited by MDD status, gender, and age.

Measurements

Participants underwent fMR

SUBMITTER: Briceno EM 

PROVIDER: S-EPMC4241383 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature