Ontology highlight
ABSTRACT:
SUBMITTER: Lohr JG
PROVIDER: S-EPMC4241387 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Cancer cell 20140101 1
We performed massively parallel sequencing of paired tumor/normal samples from 203 multiple myeloma (MM) patients and identified significantly mutated genes and copy number alterations and discovered putative tumor suppressor genes by determining homozygous deletions and loss of heterozygosity. We observed frequent mutations in KRAS (particularly in previously treated patients), NRAS, BRAF, FAM46C, TP53, and DIS3 (particularly in nonhyperdiploid MM). Mutations were often present in subclonal pop ...[more]