Enhancement of T-cell-mediated antitumor response: angiostatic adjuvant to immunotherapy against cancer.

ABSTRACT:

Purpose

Tumor-released proangiogenic factors suppress endothelial adhesion molecule (EAM) expression and prevent leukocyte extravasation into the tumor. This is one reason why immunotherapy has met with limited success in the clinic. We hypothesized that overcoming EAM suppression with angiogenesis inhibitors would increase leukocyte extravasation and subsequently enhance the effectiveness of cellular immunotherapy.

Experimental design

Intravital microscopy, multiple color flow cytometry, immunohistochemistry, and various tumor mouse (normal and T-cell deficient) models were used to investigate the temporal dynamics of cellular and molecular events that occur in the tumor microenvironment during tumor progression and angiostatic intervention.

Results

We report that wh

SUBMITTER: Dings RP 

PROVIDER: S-EPMC4242153 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature