Distinct, genome-wide, gene-specific selectivity patterns of four glucocorticoid receptor coregulators.

ABSTRACT: Glucocorticoids are a class of steroid hormones that bind to and activate the glucocorticoid receptor (GR), which then positively or negatively regulates transcription of many genes that govern multiple important physiological pathways such as inflammation and metabolism of glucose, fat and bone. The remodeling of chromatin and regulated assembly or disassembly of active transcription complexes by GR and other DNA-binding transcription factors is mediated and modulated by several hundred transcriptional coregulator proteins. Previous studies focusing on single coregulators demonstrated that each coregulator is required for regulation of only a subset of all the genes regulated by a steroid hormone. We hypothesized that the gene-specific patterns of coregulators may correspond to specific p

SUBMITTER: Wu DY 

PROVIDER: S-EPMC4242289 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature