Further evidence of association between amphetamine response and SLC6A2 gene variants.

ABSTRACT:

Background and rationale

We previously found that the intronic norepinephrine transporter gene (SLC6A2) polymorphism rs36017 modulates feelings of elation after administration of 20 mg D-amphetamine in healthy volunteers.

Objectives

In this study, we further investigated the association between D-amphetamine response and 11 SLC6A2 single-nucleotide polymorphisms (SNPs), including rs36017, in an extended sample of Caucasian young adults.

Methods

One hundred fifty-nine healthy volunteers participated in a three-session double-blind crossover design receiving either placebo or oral D-amphetamine (10 and 20 mg). Based on our previous results, we examined the associations between levels of self-reported elation and vigor after D-amphetamine administration and SNPs and SNP

SUBMITTER: Dlugos AM 

PROVIDER: S-EPMC4242585 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature