Genetics of caffeine consumption and responses to caffeine.

ABSTRACT:

Rationale

Caffeine is widely consumed in foods and beverages and is also used for a variety of medical purposes. Despite its widespread use, relatively little is understood regarding how genetics affects consumption, acute response, or the long-term effects of caffeine.

Objective

This paper reviews the literature on the genetics of caffeine from the following: (1) twin studies comparing heritability of consumption and of caffeine-related traits, including withdrawal symptoms, caffeine-induced insomnia, and anxiety, (2) association studies linking genetic polymorphisms of metabolic enzymes and target receptors to variations in caffeine response, and (3) case-control and prospective studies examining relationship between polymorphisms associated with variations in caffeine res

SUBMITTER: Yang A 

PROVIDER: S-EPMC4242593 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature