Exploring the distribution of genetic markers of pharmacogenomics relevance in Brazilian and Mexican populations.

ABSTRACT: Studies of pharmacogenomics-related traits are increasingly being performed to identify loci that affect either drug response or susceptibility to adverse drug reactions. However, the effect of the polymorphisms can differ in magnitude or be absent depending on the population being assessed. We used the Affymetrix Drug Metabolizing Enzymes and Transporters (DMET) Plus array to characterize the distribution of polymorphisms of pharmacogenetics and pharmacogenomics (PGx) relevance in two samples from the most populous Latin American countries, Brazil and Mexico. The sample from Brazil included 268 individuals from the southeastern state of Rio de Janeiro, and was stratified into census categories. The sample from Mexico comprised 45 Native American Zapotecas and 224 self-identified Mestizo i

SUBMITTER: Bonifaz-Pena V 

PROVIDER: S-EPMC4242606 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature