Protein loop modeling using a new hybrid energy function and its application to modeling in inaccurate structural environments.

ABSTRACT: Protein loop modeling is a tool for predicting protein local structures of particular interest, providing opportunities for applications involving protein structure prediction and de novo protein design. Until recently, the majority of loop modeling methods have been developed and tested by reconstructing loops in frameworks of experimentally resolved structures. In many practical applications, however, the protein loops to be modeled are located in inaccurate structural environments. These include loops in model structures, low-resolution experimental structures, or experimental structures of different functional forms. Accordingly, discrepancies in the accuracy of the structural environment assumed in development of the method and that in practical applications present additional challen

SUBMITTER: Park H 

PROVIDER: S-EPMC4242723 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature