Intensive blood pressure control, falls, and fractures in patients with type 2 diabetes: the ACCORD trial.

ABSTRACT:

Background

There are few rigorous studies to confirm or refute the commonly cited concern that control of blood pressure to lower thresholds may result in an increased risk of falls and fractures.

Objective

To compare falls and fractures in participants with type 2 diabetes in the intensive (targeting a systolic blood pressure of < 120 mmHg) and standard (targeting a systolic blood pressure of < 140 mmHg) blood pressure control arms of the Action to Control Cardiovascular Risk in Diabetes (ACCORD) randomized trial (N = 4,733).

Participants

A subset of 3,099 participants self-reported annually on the occurrence of falls and non-spine fractures. Fractures were centrally adjudicated.

Main measures

The incidence of falls in the two treatment groups was compared usi

SUBMITTER: Margolis KL 

PROVIDER: S-EPMC4242873 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature