Polymorphism of the IL-18 and CD40 genes and Liver Transplant Outcome in Iranian Patients.

ABSTRACT:

Background

Cytokines and co-stimulatory molecules are important factors determining the outcome of transplantation.

Objective

To investigate the effect of IL-18 and CD40 gene polymorphisms on the outcome of liver transplantation.

Methods

150 liver transplant recipients were included in this study. Alleles and genotypes frequencies for IL-18 (rs1946519) and CD40 (rs1883832) were determined in 28 acutely rejected (AR group) and 122 non-acutely rejected (non-AR group) liver transplant recipients. IL-18 and CD40 gene polymorphisms were evaluated by PCR-RFLP methods.

Results

There were no significant associations between IL-18 and CD40 polymorphism with acute rejection in liver transplant patients. IL-18TT and TG genotypes had a significant association with rejectio

SUBMITTER: Hejr S 

PROVIDER: S-EPMC4243046 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature