Discovering co-occurring patterns and their biological significance in protein families.

ABSTRACT:

Background

The large influx of biological sequences poses the importance of identifying and correlating conserved regions in homologous sequences to acquire valuable biological knowledge. These conserved regions contain statistically significant residue associations as sequence patterns. Thus, patterns from two conserved regions co-occurring frequently on the same sequences are inferred to have joint functionality. A method for finding conserved regions in protein families with frequent co-occurrence patterns is proposed. The biological significance of the discovered clusters of conserved regions with co-occurrences patterns can be validated by their three-dimensional closeness of amino acids and the biological functionality found in those regions as supported by published work.

SUBMITTER: Lee ES 

PROVIDER: S-EPMC4243116 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature