Prediction of disease genes using tissue-specified gene-gene network.

ABSTRACT:

Background

Tissue specificity is an important aspect of many genetic diseases in the context of genetic disorders as the disorder affects only few tissues. Therefore tissue specificity is important in identifying disease-gene associations. Hence this paper seeks to discuss the impact of using tissue specificity in predicting new disease-gene associations and how to use tissue specificity along with phenotype information for a particular disease.

Methods

In order to find out the impact of using tissue specificity for predicting new disease-gene associations, this study proposes a novel method called tissue-specified genes to construct tissues-specific gene-gene networks for different tissue samples. Subsequently, these networks are used with phenotype details to predict disea

SUBMITTER: Ganegoda G 

PROVIDER: S-EPMC4243117 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature