Exploration of molecular genetic etiology for Korean cochlear implantees with severe to profound hearing loss and its implication.

ABSTRACT:

Background

Severe to profound sensorineural hearing loss (SNHL) requires cochlear implantation (CI) for auditory rehabilitation. Etiologic diagnoses can contribute to candidacy selection and decision-making regarding the timing of successful CI. However, few studies have been performed to address the etiologic spectrum of severe SNHL in the population where there is no consanguineous marriage and the majority of SNHL cases are sporadic in small sized families. The authors sought to comprehensively understand the etiologies of Korean cochlear implantees by incorporating the targeted resequencing of 204 candidate deafness genes (TRS-204) and a phenotype-driven candidate gene approach.

Methods

Ninety-three that consented to molecular genetic testing and underwent at least one m

SUBMITTER: Park JH 

PROVIDER: S-EPMC4243193 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature