Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez E
PROVIDER: S-EPMC4243245 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Nature communications 20141113
Chlamydia, a major human bacterial pathogen, assumes effective strategies to protect infected cells against death-inducing stimuli, thereby ensuring completion of its developmental cycle. Paired with its capacity to cause extensive host DNA damage, this poses a potential risk of malignant transformation, consistent with circumstantial epidemiological evidence. Here we reveal a dramatic depletion of p53, a tumor suppressor deregulated in many cancers, during Chlamydia infection. Using biochemical ...[more]