Cecropin P1 inhibits porcine reproductive and respiratory syndrome virus by blocking attachment.

ABSTRACT:

Background

Porcine reproductive and respiratory syndrome virus (PRRSV) is a continuous threat to the pig industry, causing high economic losses worldwide. Current vaccines have specific limitations in terms of their safety and efficacy, so the development of novel antiviral drugs is urgently required. The aim of this study was to evaluate the inhibitory effects and underlying molecular mechanisms of the antimicrobial peptide cecropin P1 (CP1) against PRRSV infection in vitro.

Results

CP1 not only displayed extracellular virucidal activity against PRRSV, but also exerted a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation. The inhibitory effect of CP1 occurred during viral attachment, but not at viral entry into Marc-145 cells.

SUBMITTER: Guo C 

PROVIDER: S-EPMC4243277 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature