Mesenchymal precursor cells as adjunctive therapy in recipients of contemporary left ventricular assist devices.

ABSTRACT:

Background

Allogeneic mesenchymal precursor cells (MPCs) injected during left ventricular assist device (LVAD) implantation may contribute to myocardial recovery. This trial explores the safety and efficacy of this strategy.

Methods and results

In this multicenter, double-blind, sham-procedure controlled trial, 30 patients were randomized (2:1) to intramyocardial injection of 25 million MPCs or medium during LVAD implantation. The primary safety end point was incidence of infectious myocarditis, myocardial rupture, neoplasm, hypersensitivity reaction, and immune sensitization (90 days after randomization). Key efficacy end points were functional status and ventricular function while temporarily weaned from LVAD support (90 days after randomization). Patients were followed up

SUBMITTER: Ascheim DD 

PROVIDER: S-EPMC4243683 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature