Primary lung adenocarcinomas in children and adolescents treated for pediatric malignancies.

ABSTRACT:

Introduction

Primary lung adenocarcinoma is extremely rare in the pediatric age group. There have been anecdotal reports of lesions that are histologically indistinguishable from adult-type pulmonary adenocarcinoma in young patients after treatment for nonpulmonary cancers. Herein, we present clinical, histopathologic, and molecular data on eight such cases.

Methods

Histopathologic evaluation of the tumors was performed according to the World Health Organization classification. Molecular studies for EGFR and KRAS mutations were performed on six patients with sufficient material.

Results

All eight patients were never smokers, four males and four females. Median age at nonpulmonary cancer diagnosis was 14 years (range, 3-23 years). Pulmonary adenocarcinomas were diagnos

SUBMITTER: Kayton ML 

PROVIDER: S-EPMC4243865 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature