Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling.

ABSTRACT:

Aims

The aim was to develop a theory-based population pharmacokinetic model of tacrolimus in adult kidney transplant recipients and to externally evaluate this model and two previous empirical models.

Methods

Data were obtained from 242 patients with 3100 tacrolimus whole blood concentrations. External evaluation was performed by examining model predictive performance using Bayesian forecasting.

Results

Pharmacokinetic disposition parameters were estimated based on tacrolimus plasma concentrations, predicted from whole blood concentrations, haematocrit and literature values for tacrolimus binding to red blood cells. Disposition parameters were allometrically scaled to fat free mass. Tacrolimus whole blood clearance/bioavailability standardized to haematocrit of 45% an

SUBMITTER: Storset E 

PROVIDER: S-EPMC4243902 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature