Acute bronchodilator responses decline progressively over 4 years in patients with moderate to very severe COPD.

ABSTRACT:

Background

We previously reported a progressive decline in absolute responses of FEV1 and FVC to a near-maximal dose of 2 different short-acting bronchodilators over 4 years. Since varying host factors and the method of expressing the response may impact the time trend of acute bronchodilator responses, we now examined the potential influence of salient host characteristics on changes in bronchodilator responses over time expressed in different ways.

Methods

As part of the 4-year, placebo-controlled Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT) trial, pre- and post-bronchodilator spirometry was performed at baseline and 1 month and every 6 months thereafter. Post-bronchodilator values for FEV1 and FVC were analyzed for subjects completing at

SUBMITTER: Tashkin DP 

PROVIDER: S-EPMC4244051 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature