Human Staufen1 associates to miRNAs involved in neuronal cell differentiation and is required for correct dendritic formation.

ABSTRACT: Double-stranded RNA-binding proteins are key elements in the intracellular localization of mRNA and its local translation. Staufen is a double-stranded RNA binding protein involved in the localised translation of specific mRNAs during Drosophila early development and neuronal cell fate. The human homologue Staufen1 forms RNA-containing complexes that include proteins involved in translation and motor proteins to allow their movement within the cell, but the mechanism underlying translation repression in these complexes is poorly understood. Here we show that human Staufen1-containing complexes contain essential elements of the gene silencing apparatus, like Ago1-3 proteins, and we describe a set of miRNAs specifically associated to complexes containing human Staufen1. Among these, miR-124

SUBMITTER: Peredo J 

PROVIDER: S-EPMC4244161 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature