Pre-existing atrial fibrillation and risk of arterial thromboembolism and death following pneumonia: a population-based cohort study.

ABSTRACT:

Objectives

To examine the effect of pre-existing atrial fibrillation (AF) and associated therapy on the risk of arterial thromboembolism (ATE) and death following pneumonia.

Design, setting and participants

Population-based cohort study (1997-2012) of 88,315 patients with first-time hospitalisation with pneumonia in Northern Denmark.

Results

Of the included patients (median age 73.4 years), 8880 (10.1%) had pre-existing AF. The risk of ATE within 30 days of admission was 5.2% in patients with AF and 3.6% in patients without AF. After adjustment for higher age and comorbidity, the adjusted HR (aHR) with AF was 1.06 (95% CI 0.96 to 1.18). Among patients with AF, reduced risk of ATE was observed in vitamin-K antagonist users compared with non-users (aHR 0.74 (95% CI 0.61

SUBMITTER: Gamst J 

PROVIDER: S-EPMC4244399 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature