Classification of osteoarthritis phenotypes by metabolomics analysis.

ABSTRACT:

Objectives

To identify metabolic markers that can classify patients with osteoarthritis (OA) into subgroups.

Design

A case-only study design was utilised.

Participants

Patients were recruited from those who underwent total knee or hip replacement surgery due to primary OA between November 2011 and December 2013 in St. Clare's Mercy Hospital and Health Science Centre General Hospital in St. John's, capital of Newfoundland and Labrador (NL), Canada. 38 men and 42 women were included in the study. The mean age was 65.2±8.7 years.

Outcome measures

Synovial fluid samples were collected at the time of their joint surgeries. Metabolic profiling was performed on the synovial fluid samples by the targeted metabolomics approach, and various analytic methods were utilised

SUBMITTER: Zhang W 

PROVIDER: S-EPMC4244434 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature