Beta-blockers reduced the risk of mortality and exacerbation in patients with COPD: a meta-analysis of observational studies.

ABSTRACT:

Background

Cardiovascular disease is a primary cause of death in patients with chronic obstructive pulmonary disease (COPD). Beta-blockers have been proved to reduce morbidity and improve survival in patients with cardiac diseases. But the effects of beta-blockers on outcomes in patients with COPD remain controversial. The objective of this meta-analysis was to assess the effect of beta-blockers on mortality and exacerbation in patients with COPD.

Methods

An extensive search of the EMBASE, MEDLINE and Cochrane was performed to retrieve the studies of beta-blockers treatment in patients with COPD. The random effects model meta-analysis was used to evaluate effect on overall mortality and exacerbation of COPD.

Results

Fifteen original observational cohort studies with a

SUBMITTER: Du Q 

PROVIDER: S-EPMC4245088 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature