Measuring adherence to antiretroviral therapy in children and adolescents in western Kenya.

ABSTRACT:

Introduction

High levels of adherence to antiretroviral therapy (ART) are central to HIV management. The objective of this study was to compare multiple measures of adherence and investigate factors associated with adherence among HIV-infected children in western Kenya.

Methods

We evaluated ART adherence prospectively for six months among HIV-infected children aged ≤14 years attending a large outpatient HIV clinic in Kenya. Adherence was reported using caregiver report, plasma drug concentrations and Medication Event Monitoring Systems (MEMS®). Kappa statistics were used to compare adherence estimates with MEMS®. Logistic regression analyses were performed to assess the association between child, caregiver and household characteristics with dichotomized adherence (MEMS® adhe

SUBMITTER: Vreeman RC 

PROVIDER: S-EPMC4245448 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature