Standing genetic variation drives repeatable experimental evolution in outcrossing populations of Saccharomyces cerevisiae.

ABSTRACT: In "evolve-and-resequence" (E&R) experiments, whole-genome sequence data from laboratory-evolved populations can potentially uncover mechanisms of adaptive change. E&R experiments with initially isogenic, asexually reproducing microbes have repeatedly shown that beneficial de novo mutations drive adaptation, and these mutations are not shared among independently evolving replicate populations. Recent E&R experiments with higher eukaryotes that maintain genetic variation via sexual reproduction implicate largely different mechanisms; adaptation may act primarily on pre-existing genetic variation and occur in parallel among independent populations. But this is currently a debated topic, and generalizing these conclusions is problematic because E&R experiments with sexual species are difficul

SUBMITTER: Burke MK 

PROVIDER: S-EPMC4245818 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature