Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice.

ABSTRACT:

Background

Liver X receptor (LXR) plays a critical regulatory role in metabolism and inflammation, and has been demonstrated to be involved in cardiovascular physiology/pathology. In the present study, we investigated the effect of GW3965, a potent LXR agonist, on diabetic cardiomyopathy (DCM) in type 2 diabetic db/db mice.

Methods and results

Non-diabetic db/+ mice and diabetic db/db mice received either vehicle or LXR agonist GW3965 for 12 weeks. Systemic insulin resistance was evaluated by glucose tolerance test and homeostasis model assessment for insulin resistance. Endpoint cardiac function was assessed by echocardiography and catheterization. Ventricular tissue was collected for histology and gene/protein expression analysis. Untreated db/db diabetic mice exhibited di

SUBMITTER: He Q 

PROVIDER: S-EPMC4245833 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature