P62/SQSTM1 plays a protective role in oxidative injury of steatotic liver in a mouse hepatectomy model.

ABSTRACT:

Aims

Liver injury and regeneration involve complicated processes and are affected by various physio-pathological factors. We investigated the mechanisms of steatosis-associated liver injury and delayed regeneration in a mouse model of partial hepatectomy.

Results

Initial regeneration of the steatotic liver was significantly delayed after hepatectomy. Although hepatocyte proliferation was not significantly suppressed, severe liver injury with oxidative stress (OS) occurred immediately after hepatectomy in the steatotic liver. Fas-ligand (FasL)/Fas expression was upregulated in the steatotic liver, whereas the expression of antioxidant and anti-apoptotic molecules (catalase/MnSOD/Ref-1 and Bcl-2/Bcl-xL/FLIP, respectively) and p62/SQSTM1, a steatosis-associated protein, was dow

SUBMITTER: Haga S 

PROVIDER: S-EPMC4245881 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature