FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet.

ABSTRACT: Although overweight and obesity are associated with poor health outcomes in the elderly, the biological bases of obesity-related behaviors during aging are poorly understood. Common variants in the FTO gene are associated with adiposity in children and younger adults as well as with adverse mental health in older individuals. However, it is unclear whether FTO influences longitudinal trajectories of adiposity and other intermediate phenotypes relevant to mental health during aging. We examined whether a commonly carried obesity-risk variant in the FTO gene (rs1421085 single-nucleotide polymorphism) influences adiposity and is associated with changes in brain function in participants within the Baltimore Longitudinal Study of Aging, one of the longest-running longitudinal aging studies in t

SUBMITTER: Chuang YF 

PROVIDER: S-EPMC4246032 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature