A genetic risk tool for obesity predisposition assessment and personalized nutrition implementation based on macronutrient intake.

ABSTRACT: There is little evidence about genetic risk score (GRS)-diet interactions in order to provide personalized nutrition based on the genotype. The aim of the study was to assess the value of a GRS on obesity prediction and to further evaluate the interactions between the GRS and dietary intake on obesity. A total of 711 seekers of a Nutrigenetic Service were examined for anthropometric and body composition measurements and also for dietary habits and physical activity. Oral epithelial cells were collected for the identification of 16 SNPs (related with obesity or lipid metabolism) using DNA zip-coded beads. Genotypes were coded as 0, 1 or 2 according to the number of risk alleles, and the GRS was calculated by adding risk alleles with such a criterion. After being adjusted for gender, age, ph

SUBMITTER: Goni L 

PROVIDER: S-EPMC4246034 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature