Ontology highlight
ABSTRACT:
SUBMITTER: Fonville JM
PROVIDER: S-EPMC4246172 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20141101 6212
We introduce the antibody landscape, a method for the quantitative analysis of antibody-mediated immunity to antigenically variable pathogens, achieved by accounting for antigenic variation among pathogen strains. We generated antibody landscapes to study immune profiles covering 43 years of influenza A/H3N2 virus evolution for 69 individuals monitored for infection over 6 years and for 225 individuals pre- and postvaccination. Upon infection and vaccination, titers increased broadly, including ...[more]