Proteomic analysis of rat cartilage: the identification of differentially expressed proteins in the early stages of osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA) is a chronic degenerative disease of the articular cartilage, and its diagnosis is based on symptoms and radiological signs that are only present in the late stages of the disease. Due to the limitations in diagnosing OA before the onset of symptoms, such as pain, little is known about the molecular mechanisms involved in the pathogenesis of OA. Experimental OA models are often used to study the kinetics of the progression of this disease. In this report, we conducted a proteomic study of osteoarthritic cartilage during the early stages of OA using an experimental rat model.

Results

Ten proteins that are differentially expressed under early OA conditions were identified by 2-DE and MALDI-TOF/MS. These proteins mediated many processes, such as g

SUBMITTER: Parra-Torres NM 

PROVIDER: S-EPMC4246440 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature