Mapping of a blood pressure QTL on chromosome 17 in American Indians of the strong heart family study.

ABSTRACT:

Background

Blood pressure (BP) is a complex trait, with a heritability of 30 to 40%. Several genome wide associated BP loci explain only a small fraction of the phenotypic variation. Family studies can provide an important tool for gene discovery by utilizing trait and genetic transmission information among relative-pairs. We have previously described a quantitative trait locus at chromosome 17q25.3 influencing systolic BP in American Indians of the Strong Heart Family Study (SHFS). This locus has been reported to associate with variation in BP traits in family studies of Europeans, African Americans and Hispanics.

Methods

To follow-up persuasive linkage findings at this locus, we performed comprehensive genotyping in the 1-LOD unit support interval region surrounding this Q

SUBMITTER: Franceschini N 

PROVIDER: S-EPMC4246441 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature