Diplotypes of CYP2C9 gene is associated with coronary artery disease in the Xinjiang Han population for women in China.

ABSTRACT:

Background

Cytochrome P450 (CYP) 2C9 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have the crucial role in the modulation of cardiovascular homeostasis. We sought to assess the association between the human CYP2C9 gene and coronary artery disease (CAD) in Xinjiang Han Population of China.

Methods

301 CAD patients and 220 control subjects were genotyped for 4 single-nucleotide polymorphisms (SNPs) of the human CYP2C9 gene (rs4086116, rs2475376, rs1057910, and rs1934967) by a Real-Time PCR instrument. The datas were assessed for 3 groups: total, men, and women via diplotype-based case-control study.

Results

For women, the distribution of genotypes, dominant model and alleles of S

SUBMITTER: Fu Z 

PROVIDER: S-EPMC4246459 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature