MicroRNA-940 suppresses prostate cancer migration and invasion by regulating MIEN1.

ABSTRACT:

Background

MicroRNAs (miRNAs) are crucial molecules that regulate gene expression and hence pathways that are key to prostate cancer progression. These non-coding RNAs are highly deregulated in prostate cancer thus facilitating progression of the disease. Among the many genes that have gained importance in this disease, Migration and invasion enhancer 1 (MIEN1), a novel gene located next to HER2/neu in the 17q12 amplicon of the human chromosome, has been shown to enhance prostate cancer cell migration and invasion, two key processes in cancer progression. MIEN1 is differentially expressed between normal and cancer cells and tissues. Understanding the regulation of MIEN1 by microRNA may enable development of better targeting strategies.

Methods

The miRNAs that could target MI

SUBMITTER: Rajendiran S 

PROVIDER: S-EPMC4246551 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature