Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R.

ABSTRACT: Precise spatiotemporal control of mRNA translation machinery is essential to the development of highly complex systems like the neocortex. However, spatiotemporal regulation of translation machinery in the developing neocortex remains poorly understood. Here, we show that an RNA-binding protein, Hu antigen R (HuR), regulates both neocorticogenesis and specificity of neocortical translation machinery in a developmental stage-dependent manner in mice. Neocortical absence of HuR alters the phosphorylation states of initiation and elongation factors in the core translation machinery. In addition, HuR regulates the temporally specific positioning of functionally related mRNAs into the active translation sites, the polysomes. HuR also determines the specificity of neocortical polysomes by defini

SUBMITTER: Kraushar ML 

PROVIDER: S-EPMC4246959 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature