Transforming growth factor-β1 rs1800470 polymorphism is associated with lung cancer risk: a meta-analysis.

ABSTRACT:

Background

Transforming growth factor-β1 is a member of a large class of polypeptides that regulate the proliferation, differentiation, and carcinogenesis of epithelial cells. The rs1800470 polymorphism influences transforming growth factor-β1 expression and has been associated with lung cancer susceptibility. However, the association between the rs1800470 polymorphism and lung cancer risk remains controversial. Thus, a meta-analysis was conducted.

Material/methods

We comprehensively searched PubMed and EMBASE databases. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models or fixed-effects models.

Results

Overall, there was a significant association between rs1800470 polymorphism and lung cancer suscepti

SUBMITTER: Fan H 

PROVIDER: S-EPMC4247234 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature