Antibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysis.

ABSTRACT:

Objective

To investigate the association between exposure to antibiotics in fetal and early life and asthma in childhood, with adjustment for confounding factors.

Design

Nationwide prospective population based cohort study, including sibling control design.

Setting

Swedish population identified from national demographic and health registers.

Participants

493,785 children born 2006-10; 180,894 of these were eligible for sibling analyses.

Main outcome measure

Asthma defined as having both an asthma diagnosis and dispensed asthma drugs. The association between antibiotic exposure and asthma was investigated in the whole cohort with Cox proportional hazard regression. A stratified proportional hazards model conditional on sibling group was used to adjust for

SUBMITTER: Ortqvist AK 

PROVIDER: S-EPMC4247260 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature