Gene expression of tendon markers in mesenchymal stromal cells derived from different sources.

ABSTRACT:

Background

Multipotent mesenchymal stromal cells (MSC) can be recovered from a variety of tissues in the body. Yet, their functional properties were shown to vary depending on tissue origin. While MSC have emerged as a favoured cell type for tendon regenerative therapies, very little is known about the influence of the MSC source on their properties relevant to tendon regeneration.The aim of this study was to assess and compare the expression of tendon extracellular matrix proteins and tendon differentiation markers in MSC derived from different sources as well as in native tendon tissue. MSC isolated from equine bone marrow, adipose tissue, umbilical cord tissue, umbilical cord blood and tendon tissue were characterized and then subjected to mRNA analysis by real-time polymerase c

SUBMITTER: Burk J 

PROVIDER: S-EPMC4247609 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature